This magical potion was used many times in the novels, from Hermione's batch in Myrtle's bathroom to the seven Potters scene in Deathly Hallows and beyond.
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Polyjuice potion is made with Lacewing flies, leeches, fluxweed, knotgrass, powdered horn of a bicorn, shredded skin of a boomslang, and a bit of whoever one wants to change into. The fluxweed needs to be picked at the full moon and the lacewings have got to be stewed for twenty-one days so the potion takes about a month to prepare.
The Polyjuice Potion is first described as looking like "thick, dark mud, bubbling sluggishly". When Harry is offically taught about the potion by Horace Slughorn and he again describes it as a "slow-bubbling, mudlike substance".